doi: 10.1161/01.CIR.91.6.1739, 24. doi: 10.1136/bjsm.2005.022194, 8. Job Title. 25 people like this. Under optimal conditions (i.e., good quality images), only volume, CS and PTS 3D-STE derived dyssynchrony indices achieved fair to good test-retest reliability, whereas LS and RS derived dyssynchrony indices showed poor test-retest reliability (Table 2). To our knowledge, no study has provided detailed estimates of dengue-related incidence, mortality, DALYs in 195 countries and territories around the world for several years. Create New Account. People working at Sdis 57. En poursuivant votre navigation, vous acceptez le dépôt de cookies tiers destinés à collecter vos informations par le Service Départemental d’Incendie et de Secours de Moselle (SDIS 57) ayant pour finalité la prise de contact et les renseignements de recrutement des différents personnels du SDIS 57. Meanwhile, the global age-standardised death rate increased from 0.31 (0.14–0•56) per 100 000 population in 1990 to 0.53 (0.23–0•65) per 100 000 population in 2017. However, the authors highlighted the lack of estimates of test-retest reliability which is the relevant measure for follow-up assessments of LVMD. 25 people follow this. Circulation. Dit geldt ook voor een aantal in behandeling zijnde serviceverzoeken. Bekijk het volledige profiel op LinkedIn om de connecties van test en vacatures bij vergelijkbare bedrijven te zien. doi: 10.1093/eurheartj/ehv418, 9. (2011) 108:867–72. Er vinden maximaal zes behandelingen plaats. $169.95 For a test to be useful it must be reproducible, i.e., show acceptable variability between measures (good reliability) and demonstrate no systematic differences between measurement occasions (no bias) (17). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. LVMD can be measured by several echocardiographic imaging modalities such tissue-Doppler imaging (TDI), 2D speckle-tracking echocardiography (STE), 3D echocardiography (3DE), and 3D-STE (11). Bekijk de Helpende (Intramuraal) vacature bij DuoZorg Uitzendbureau in Spijkenisse op Usefulness of three-dimensional speckle tracking strain to quantify dyssynchrony and the site of latest mechanical activation. We believe this analysis presents the most comprehensive picture of dengue burden to date. Dengue is a major public health challenge worldwide. The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Descriptive epidemiology of SARS-CoV-2 infection in Karnataka state, South India: Transmission dynamics of symptomatic vs. asymptomatic infections, Mifepristone followed by misoprostol compared with placebo followed by misoprostol as medical treatment for early pregnancy loss (the Triple M trial): A double-blind placebo-controlled randomised trial, Implications of all the available evidence. Tanaka H, Hara H, Adelstein EC, Schwartzman D, Saba S, Gorcsan J III. MB), Download .xls (.28 doi: 10.1016/j.amjcard.2011.05.015, 23. 30 November 2020 13:58 GMT Updated 30 November 2020 13:58 GMT By Demi Korban doi: 10.1016/j.amjcard.2010.09.038, Keywords: 3D speckle tracking, left ventricular dyssynchrony, image quality, test-retest reliability, reproducibility, Citation: Al Saikhan L, Park C and Hughes AD (2019) Reproducibility of Left Ventricular Dyssynchrony Indices by Three-Dimensional Speckle-Tracking Echocardiography: The Impact of Sub-optimal Image Quality. 32. We show that LV dyssynchrony indices based on CS and PTS have fair to good test-retest reliability only when images are optimal, reliability is generally poor for sub-optimal images. Sample size formulas for estimating intraclass correlation coefficients with precision and assurance. The impact of a program for strengthening dengue hemorrhagic fever case management on the clinical outcome of dengue hemorrhagic fever patients. Am J Cardiol. Rupee settles 3 paise higher at 73.57 against US dollar At the interbank forex market, Rupee opened at 73.58 against the US dollar and witnessed an intra-day high of 73.49 and a low of 73.61. Kleijn SA, Aly MF, Knol DL, Terwee CB, Jansma EP, Abd El-Hady YA, et al. Natuurlijk Intratuin! (2012) 29:598–607. This could be partly explained by sex-related physiology [. For but, as the author acknowledges, is limited in scope example, an expert in a resource agency may find and cannot be recognized as a complete set of SDIs. (2011) 24:277–313. (1995) 91:1739–48. Wij willen hier een beschrijving geven, maar de site die u nu bekijkt staat dit niet toe. The software then subdivided the LV into 16 segments using a standard model (31) and provided curves as well as maps of global and segmental volumetric and deformation indices. We chose it as many of its acoustic properties are similar to soft biological tissues, it is durable, and it has a comparatively high attenuation coefficient (28, 29). 2020. Results: Test-retest reproducibility was better for most indices when restricting the analysis to good quality images; nevertheless, only volume-, circumferential strain-, and principal tangential strain-derived LV dyssynchrony indices achieved fair to good reliability. Strain echocardiography improves risk prediction of ventricular arrhythmias after myocardial infarction. Test-retest reliability was quantified by intraclass correlation coefficients (ICC). December 18, Three-dimensional echocardiographic (3DE) strain derived systolic dyssynchrony index (SDI) and impaired quality 3DE images. Cardiovasc. Echocardiography. 3DE examination was perfumed using an EPIQ7 ultrasound machine (Philips Medical Systems, Andover, MA) equipped with a X5-1 Xmatrix-array transducer by an experienced, British Society of Echocardiography accredited sonographer as previously described (26). Intramat Group Gildenweg 2 7641 AZ Wierden KVK: 64759474 BTW: NL 855823136 Spragg DD, Kass DA. Dengue in Fiji: epidemiology of the 2014 DENV-3 outbreak. Despite promising results, 2D-STE is limited by the requirement for non-simultaneous measurements introducing beat-to-beat variability (15). Copyright © 2019 Al Saikhan, Park and Hughes. voor Geneeskunde, 57, nr. ELIGOR 116285 1:43 SCANIA P280 CABINE CP 31 HIGH FPT HEINIS SDIS 57 FIRE TRUCK 2. De Jong Intra Vakanties krijgt gemiddeld een 8,5 op basis van 1103 ervaringen : 8,5 1103 ervaringen + Ervaring delen doi: 10.1016/j.amjcard.2009.09.010, 16. Background: 3D speckle-tracking echocardiography (3D-STE) is a novel method to quantify left ventricular (LV) mechanical dyssynchrony. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Volume-, circumferential strain-, and principal tangential strain-derived SDIs correlated closely. Ervaringen De Jong Intra Vakanties. Proc Physiol Soc. Effects of temperature and larval diet on development rates and survival of the dengue vector Aedes aegypti in north Queensland, Australia. doi: 10.1016/j.jacc.2007.06.043, 14. Reproducibility was fair to good for LS-SDI, but poor for LS-Di. Dengue: guidelines for diagnosis, treatment, prevention and control. Intraventricular dyssynchrony predicts mortality and morbidity after cardiac resynchronization therapy: a study using cardiovascular magnetic resonance tissue synchronization imaging. This work was supported by a grant from the National Natural Science Foundation of China (NSFC) (grant numbers 81,800,041 and 82,000,078). The effect of image quality on test-retest reproducibility of 3D-STE derived dyssynchrony indices has not been reported and evidence on systematic bias related to image quality is limited. Please enter a term before submitting your search. Dengue is the most rapidly spreading mosquito-borne viral disease worldwide. Table 5. However, under optimal conditions only volume, CS and PTS 3D-STE derived dyssynchrony indices achieved fair to good test-retest reliability. Eur Heart J Cardiovasc Imaging. doi: 10.1093/ehjci/jes041, 17. The results of the GBD 2017 can be valuable for public health officials and policy makers implementing cost-effective interventions to address the future dengue burden. Even with optimal quality images, only 3D-STE indices based on volume, circumferential strain and principal tangential strain showed acceptable test-retest reliability. Tatsumi K, Tanaka H, Yamawaki K, Ryo K, Omar AM, Fukuda Y, et al. Sdis 57. Business Service in San Carlos, Texas. Intra-observer reproducibility based on re-reading the same (good quality) scans and was performed by the first reader (LA) blinded to the original measurements after 2–3 months interval. Image analysis was perfumed using 4D LV-Analysis software (TomTec Imaging Systems GmbH, Germany, 2015) by a single blinded reader. ZLZ and JZ contributed to data collection, data analysis, data interpretation and literature search. This work was supported by agrant from the National Natural Science Foundation of China (NSFC) (grant numbers 81800041 and 82000078 ). Facebook is showing information to help you better understand the purpose of a Page. J Am Soc Echocardiogr. Synchronous contraction is important for overall left ventricular (LV) systolic performance (1). Global age-standardised mortality, incidence, and DALY rate of Dengue Fever in 2017. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Image, Download Hi-res 33. Fundamentals of Biostatistics, 7th ed. Boston, MA: Brooks/Cole, Cengage Learning 2011 (2011). ZLZ and JZ contributed equally to this paper. The quality of the second dataset was impaired by using an intentionally sub-optimal echocardiographic technique. Although no study has reported that the dengue virus is transmitted in a sex-dependent manner, the GBD 2017 showed that the age-standardised incidence rate was slightly higher in females than in males. The study was performed by a single observer which is a strength in that it avoids the influence of inter-observer variability but limits its applicability to typical clinical practice. Table 6. This resulted in echo drop out, shadow artifacts, or poor visualization of the endocardium A sub-optimal 3DE image was defined as the presence of at least one of the following (Figure 1B): Figure 1. Our study was performed on healthy individuals with good image quality (before image degradation) to maximize our ability to detect effects. At the start of each analysis, three standard apical views and one short-axis view were automatically selected and displayed by the software. Under optimal conditions in healthy individuals, the reliability of volume-derived and some 3D-STE strain-based LV dyssynchrony indices by test-retest was fair to good, but reliability was substantially compromised by poor image quality. Bekijk wat 1.170 klanten hebben geschreven en deel je eigen ervaringen. We found that SDI-volume correlated well with SDI derived from either PTS or CS and correlated moderately with RD-SDI, while SDI-volume correlated weakly with LS-SDI. | Lees 41-60 reviews van in totaal 1.180 Japan’s support to transport infrastructure in Africa 12 . Categorical variables are presented as counts and percentages. (2016) 17:624–32. Each author has contributed extensively to the manuscript. However, to be useful 3D-STE evaluation of LVMD needs to achieve acceptable reproducibility in the context of a clinically-relevant range of image qualities. Bekijk het product online of kom naar één van onze winkels. Dengue is one of the most common vector-borne diseases globally, however, its burden is poorly quantified. Measuring performance on the Healthcare access and quality index for 195 countries and territories and selected subnational locations: a systematic analysis from the global burden of disease study 2016. (2007) 50:1476–83. Study population characteristics. Intra-observer reproducibility based on re-reading the good quality scans (N = 10). 2020, Received: Hence, it may have advantages in guiding cardiac resynchronization therapy (CRT), although current guidelines are still based on electrical dyssynchrony criteria (10). We are grateful to all the volunteers who participated in this study. (2006) 40:244–50. Radial strain- and longitudinal strain-SDI correlated moderately or weakly with volume-SDI, respectively. (2004) 43:248–56. (2011) 12:26–32. The results of this study could be useful for policy makers to implement cost-effective interventions and reduce the dengue burden, particularly in countries with high incidence or increasing burden. It is possible therefore that LV dyssynchrony indices of different myocardial vectors may show differential associations with 3D-STE volume-based dyssynchrony indices. JACC Cardiovasc Imaging. (A) SDI derived from principle tangential strain. (2012) 55:14–24. Indonesia, the most populated country in Southeast Asia, witnessed a great increase in the age-standardised incidence rate over the study period, while in contrast, the age-standardised death and attributable DALY rate largely decreased. Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the global burden of disease study 2017. Cardiovasc Diagn Ther. (2009) 10:216–26. Theory & Practice of Sustainable Development Fall II 2015 SDIS-5500-01 3 Credits Instructor: Dr. Rachel Slocum Room: SGC 101 Office #: 304A Meeting time: Tuesday Office phone: 802-258-3539 8:30 – 12:15 Email: Office hours: 12:15-1:45 Tue/Fri. TDI-based dyssynchrony indices do not improve patient selection for CRT (12), but 2D-STE based dyssynchrony indices have demonstrated added value in selecting potential candidates for CRT even when QRS duration is borderline (13, 14). Intra-uteriene inseminatie (IUI) IUI - intra-uteriene inseminatie - is het inbrengen van zaadcellen in de baarmoederholte. (2018) 41:PCA033. Popović ZB, Thomas JD. (2008) 117:2608–16. © 2020 The Author(s). (2015) 32:1299–306. While there is remarkable international variation in its incidence, the dengue burden is increasing globally. Data on dengue burden in 195 countries and territories from 1990 to 2017 were obtained from the Global Health Data Exchange GBD Results Tool (, The SDI is a composite indicator of a geographical location's development status. Le SDIS 57. Why are some studies of cardiovascular markers unreliable? 30. Over the same interval, inter-observer reproducibility was also performed by a second reader (CP) blinded to first reader's measurements. Epidemiology of dengue hemorrhagic fever in Indonesia: analysis of five decades data from the national disease surveillance. $147.05. doi: 10.1016/j.amjcard.2011.11.059, 21. An update on dengue vaccine development, challenges, and future perspectives. 1):i363–i81. Pour vous connecter, vous avez besoin d'un login et d'un mot de passe ; si vous n'avez jamais eu de codes d'accès, rapprochez vous de votre chef de centre pour obtenir vos identifiants. SDis experiments SDpv12h was carried out as described above for 3 consecutive days during the light phase. SDIs exist at the local, regional, national, and global levels [10,11].It is also possible to identify topical, community SDIs. doi: 10.1093/ejechocard/jer021, 12. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. World Health Organization. Wasted septal work in left ventricular dyssynchrony: a novel principle to predict response to cardiac resynchronization therapy. All analyses were performed in Stata version 15.1 (StataCorp LLC, USA). Bias between VFI and PWD was 0.57 cm/s (p = 0.38) with an intercostal view and 9.89 cm/s (p < 0.001) with a subcostal view. Pour une utilisation correcte d'ArtemisWeb et des outils internes au SDIS, il est recommandé d'utiliser le navigateur Firefox. The LV endocardial borders in all three apical views were then automatically defined by the software at end-diastole and tracked throughout the cardiac cycle in 3D space from which the 3D LV endocardial shell was constructed. Despite this, there is currently a limited number of studies which have assessed the reliability of strain-based LV dyssynchrony indices by 3D-STE (15, 19–22). There was no evidence of systematic bias due to sub-optimal image quality in any of 3D-STE derived LV dyssynchrony indices in study 1 (Table 3). The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Haugaa KH, Grenne BL, Eek CH, Ersboll M, Valeur N, Svendsen JH, et al. Community See All. doi: 10.1016/j.jcmg.2009.09.020, 15. Re-reading scans may substantially underestimate scan-rescan reliability and has limited ability to detect bias; test-retest reproducibility is usually more relevant to chronic studies (17). In study 2 study, an additional 21 healthy individuals were recruited to further quantify the impact of sub-optimal image quality. Our data add to previous observations by Russo et al. All authors contributed to data acquisition, data analysis, or data interpretation, and all reviewed and approved the final version of the manuscript. Action Jean-Claude PITZ. The information provided in this study could be crucial for researchers, public health officials and health policy makers to implement cost-effective interventions to be able to confront the increasing dengue burden. The highest burden of dengue is in South Asia, Southeast Asia and the Caribbean. The method has been implemented on top of the VVC Test Model 3.0 (VTM-3.0), with the result of obtaining a gain of 0.57% with encoding and decoding run-times of 112% and 102% respectively for the All Intra configuration and a gain of 0.29% with encoding and decoding run-times of 102% and 101% respectively for the Random Access configuration. Further, manual adjustments were kept as minimal as possible. Zimbra provides open source server and client software for messaging and collaboration. 3D-STE is also constrained by limited temporal resolution and the effect of frame rate on reproducibility was not studied as this has been described by others (30), but we ensured that an adequate and consistent frame rate was maintained in all studies to avoid any bias from this source. FFP2 MASK FFP2 CE EN 149 2001 mask respiratory ffp2 mask . Metabolic pathways involving intra- and extracellular products of nonenzymatic glycation (advanced glycation end products [AGEs]) have been implicated in hyperglycemic nerve damage. Comparison of 3D-STE derived LV dyssynchrony indices by image quality (Study 2). An FFP mask is a type of protective mask certified by the European Union that serves to protect against particulates such as dust particles. JZ and HLC designed the study and accessed the database and that they confirm the accuracy of the database used. Methods: 3D-STE was performed in two groups, each comprising 18 healthy volunteers with good echocardiographic windows. Björn Rathsman, Kerstin Jensen-Urstad, Thomas Nyström, Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study, Diabetologia, 10.1007/s00125-014-3248-2, 57, 8, (1703-1710), (2014). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. J Am Soc Echocardiogr. Intra- and inter-observer agreement was highest for VFI (inter-observer intra-class correlation coefficient: ... the SDis 2.5 % and bias is 0.1 %. - Strain-based SDI, calculated as the SD of time to peak segmental strain over 16 LV-segments from LS, CS, RS, and principle tangential strain (PTS) which is a composite 3D measure of CS and LS. Front. Uit het sperma worden de beste zaadcellen geselecteerd en in de baarmoederholte ingebracht ten tijde van de eisprong. MB), Help with Ben je het eens met de sterrenscore van de Jong Intra Vakanties? 3D-STE has also emerged as a promising method for quantifying LVMD, with 3DE systolic dyssynchrony index (SDI-volume) having been proposed as a useful measure to assess LVMD and guide CRT (16). J Am Coll Cardiol. A new independent predictor of severe cardiac events in heart failure patients. We aimed therefore to (1) quantitate the impact of intentionally distorted image quality on reliability and bias of LV dyssynchrony indices by 3D-STE; (2) assess the association between SDI-volume and strain-based LV SDIs. Table 3. Figure 2. Cai Q, Ahmad M. Left ventricular dyssynchrony by three-dimensional echocardiography: current understanding and potential future clinical applications. The impact of intentional distortion of image quality on left ventricular deformation indices by three-dimensional speckle-tracking echocardiography. On the one hand, the age-standardised DALY rate per 100 000 population increased from 26.10 [11.57–46.53] in 1990 to 38.25 [21.33–51.93] in 2017 (Supplementary Table 1). Published by Elsevier Ltd. The number of cases and deaths as well as age-standardised incidence, age-adjusted mortality, and age-standardised DALYs per 100 000 population for both sexes combined were calculated and compared at the global, regional, and country levels. (2010) 105:235–42. The differences in dengue burden among SDI levels could be expected due to urbanization. With this sample size we could also detect a bias ≥ 1SD (alpha = 0.05) with 96% power. doi: 10.1002/sim.5466, 35. Intel (INTC) Intra-Day Move May Be Overdone - RBC December 29, 2020 1:57 PM EST Tweet. (2012) 109:1197–205. Samen maken we goede zorg betaalbaar. doi: 10.1093/ehjci/jey265. Thebault C, Donal E, Bernard A, Moreau O, Schnell F, Mabo P, et al. 6:149. doi: 10.3389/fcvm.2019.00149. Sdis 57 doit être optimisé car il peut économiser jusqu'à 1.96 Mb ou 96% du volume d'origine.Les outils les plus populaires et les plus efficaces pour l'optimisation des images JPEG et … Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, et al. We also found that the increase in the age-standardised death and DALY rate paralleled that of the age-standardised incidence rate at the global and regional levels; however, the age-standardised death and DALY rate in the Southeast Asia region decreased from 1990 to 2017. Tracy CM, Epstein AE, Darbar D, DiMarco JP, Dunbar SB, Estes NA III, et al. Yet, whether intra- and interspecific competition can have non-additive effects has rarely been tested. MB), Download .xls (.63 Get his/her professional email address for free Jean Marc Tarrillion. All other relevant data are available upon request to the corresponding author. Br J Sports Med. doi: 10.1016/j.jcmg.2013.03.005, 6. Lang RM, Badano LP, Tsang W, Adams DH, Agricola E, Buck T, et al. December 22, $173.00 + $15.95 shipping . Toen in maart de coronacrisis uitbrak, stond de zorg meteen in de hoogste versnelling. Individuals in study 2 were 31 ± 6 years old and 15 (83.3%) were men. In a large meta-analysis, 3DE demonstrated 94% feasibility for the assessment of LVMD, and SDI-volume showed good intra- and inter-observer reproducibility based on re-reading scans [interobserver ICC = 0.92 (95% CI 0.88, 0.95) and intraobserver ICC = 0.95 (95% CI 0.93, 0.97)] (16). Age-standardised DALY rate, age-standardised mortality rate and age-standardised incidence rate per 100 000 people with dengue fever in males (men and boys), females (women and girls), and both sexes from 1990 to 2017. Under suboptimal conditions the reliability of all 3D-STE LV dyssynchrony indices was poor. A good 3DE image was defined as clear visualization of the endocardium in all 16-segments in both end-diastolic and end-systolic frames. Characteristics of participants in study 1 and 2 are summarized in Table 1. Bias was assessed using Bland Altman analysis and presented as the mean difference with limits of agreement between scans of different image quality. Met de Weber Master Touch GBS E-5750 57 cm Zwart zet je iedere keer een andere barbecuecreatie op tafel. LA was supported by a scholarship grant from Imam Abdulrahman Bin Faisal University for her postgraduate studies (PhD) at UCL. The global distribution and burden of dengue. Am J Cardiol. Further work is required to establish whether differences in 3D-STE LV dyssynchrony indices have any prognostic importance. Association of persistent or worsened echocardiographic dyssynchrony with unfavourable clinical outcomes in heart failure patients with narrow QRS width: a subgroup analysis of the EchoCRT trial. Twenty non-elite youth male soccer players (U15, n = 10, mean age = 13.5 ± 1.2 years; U17, n = 10, mean age = 16.3 ± 0.5 years) were selected. (2012) 13:1–46. Duck FA. Sign In. ZLZ and HLC drafted the manuscript. Dengue is the most rapidly spreading mosquito-borne viral disease and is caused by any one of four single-stranded, positive-sense RNA viruses (DENV-1 to DENV-4) [. Eur Heart J Cardiovasc Imaging. doi: 10.1093/ejechocard/jen323, 37. All indices were normalized to cardiac cycle length and reported as %. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Mizisin and H.C. Powell The frequent occurrence of neurologic complications of diabetes has long been recognized and no doubt contributed to the erroneous belief of nineteenth-century physicians that diabetes mellitus was a disease of the nervous system. Intra-left ventricular electromechanical asynchrony. Background: 3D speckle-tracking echocardiography (3D-STE) is a novel method to quantify left ventricular (LV) mechanical dyssynchrony. We thus aimed to understand the interaction of viral infections and the nasal microbiota in early life to appraise their roles in disease development. (2006) 49:26–41. This article takes a close look at recent trends, focusing on total intra-EU trade in goods and the most traded products. The use of healthy individuals makes generalization to specific cardiac pathologies difficult but at least some of our findings are likely to be relevant to studies of diseased populations since sub-optimal image quality is more likely in unhealthy individuals. (2012) 31:3972–81. From their inception, numerous scholars, advocates, and judges have wrestled with the proper reach of DNA collection, retention, and search policies. Copyright © 2021 Elsevier Inc. except certain content provided by third parties. Some of these data have been presented previously in abstract form (24, 25). The main strength of the current study is that we used the data from the GBD 2017 estimates. 1295 Rardin Drive (1,847.50 mi) … Report 2363, Standards Branch, Underwater Sound Reference Division, Orlando, FL (1971). who showed that poor image quality impaired the reliability of LV dyssynchrony indices assessed by 3DE even when re-reading the same images (18). Dengue fever is massively under-reported in India, hampering our response. Shun-Shin M, Francis DP. Neoprene is a polymer of chloroprene, 2 chloro-1, and 3-butadiene. Marco Wilson’s inexplicable shoe toss. Inclusion of additional data in the GBD 2017 also allowed us to make national and regional-level estimates, and develop robust estimates for dengue. doi: 10.1016/j.echo.2012.06.001, 31. In this paper, we presented the most up-to-date estimates of the incidence, mortality, and DALYs for dengue in 195 countries and territories from 1990 to 2017. In summary, the global burden of dengue is substantial and increasing despite the variation between countries in incidence, mortality and DALYs. J Am Coll Cardiol. Globally, the total number of dengue cases increased from 23 283 274 (95% UI 453 180.7–51 840 670) in 1990 to 104 771 911 (95% UI 63 759 019–158 870 031) in 2017. The exceptions were Southeast Asia and South Asia where observed levels were higher than expected during every year of the study period (. We show that when image quality is optimal volume-based LV dyssynchrony indices have acceptable test-retest reliability (albeit noticeably lower than re-reading reliability), but that the test-retest reliability of volume-based LV dyssynchrony indices is substantially lower for sub-optimal images.